lolamicin

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^[1]

Indications

bacterial infection with multidrug-resistant gram-negative bacteria
- spares the gut microbiome

Mechanism of action

targets lipoprotein transport system
selective bactericidal activity for pathogenic Gram-negative bacteria results from low sequence homology for the target in pathogenic bacteria vs commensals^[1]

More general terms

antibacterial agent

References

↑ ^1.0 ^1.1 Munoz KA, Ulrich RJ, Vasan AK et al A Gram-negative-selective antibiotic that spares the gut microbiome. Nature. 2024 May 29 PMID: https://www.ncbi.nlm.nih.gov/pubmed/38811738 https://www.nature.com/articles/s41586-024-07502-0.epdf

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