EndoBarrier

Indications

• weight reduction, glycemic control, fatty liver, & need for insulin all show improvement in patients with both refractory type 2 diabetes & obesity

* efficacy remains 2 years after implant removal

Procedure

• thin impermeable sleeve is inserted via upper GI endoscopy
• the procedure lasts ~1 hour enabling the patient to return home the same day

Mechanism of action

• EndoBarrier lines the 1st 60 cm of the small intestine
• digested food passes through the small intestinal lining without absorption
• at the other end of the lining, foo makes contact with pancreatic & bile juice
• this triggers a change in the metabolism of glucose & nutrients via modulating gut hormones & gut bacteria, as well as disrupting bile flow.
• because food is encountered is in an area of intestine where it is not normally found, signals are sent to the brain to stop eating

Notes

• EndoBarrier is currently not approved in the United States

More general terms

• implant