donislecel-jujn (Lantidra)

Indications

• islet cell transplantation for adults with diabetes mellitus type 1

Dosage

• 5000 equivalent islet cells/kg for initial infusion
• 4500 equivalent islet cells/kg for subsequent infusions
• administer cells through the hepatic portal vein
• use with immunosuppression
• do not irradiate
• do not use leukodepleting filters

Adverse effects

• 90% with >= 1 serious adverse event
  • major causes
    • infusion procedure
      • liver laceration, hemorrhage (13%)
      • portal hypertension (9%)
    • immunosupression
      • infection (87%)
      • malignancy (37%)

Mechanism of action

• allogeneic pancreatic islet cell therapy

More general terms

• pancreatic islet cell transplantation