HUWE1-associated protein modifying stress responses 2 (HAPSTR2)

Function

• together with HAPSTR1 plays a central regulatory role in the cellular response to molecular stressors, such as DNA damage, nutrient scarcity, & protein misfolding
• regulates these multiple stress response signaling pathways by stabilizing HAPSTR1, but also independently of HAPSTR1
  • the interaction is direct & stabilizes HAPSTR1 independently of HUWE1
• interacts with HUWE1 (Pubmed:36631436)

Structure

• homooligomer, heterooligomer with HAPSTR1
• belongs to the HAPSTR1 family,

Compartment

nucleus

Expression

-cexpressed in a tissue-restricted manner compared to HAPSTR1

More general terms

• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=389895
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:389895
• UniProt: http://www.uniprot.org/uniprot/A0A7P0TBJ1.html