MRI brain perivascular spaces
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Pathology
- enlarged MRI brain perivascular spaces may be proxy measure of cerebral small vessel disease, glymphatic dysfunction & risk of dementia[1]
- microbleeds, cerebral amyloid angiopathy & enlarged perivascular spaces often occur in the preclinical stages of Alzheimer's disease, preceding brain atrophy[5][6]
- perivascular spaces play a role in neuroinflammation[4]
- enlarged perivascular spaces in the centrum semiovale identified in patients with chronic or episodic migraine vs healthy controls[2]
- extension & infiltration of glioblastoma multiforme occurs along perivascular spaces
Physiology
- perivascular spaces comprise the outer space between the pial membrane & astrocyte endfeet
- perivascular spaces include passageways around arterioles, capillaries & venules in the brain, along which clearance of interstitial fluid & waste from the brain occurs, particularly during sleep[3]
- they comprise the terminal end of Virchow-Robin spaces
- perivascular spaces are involved in clearing brain waste & belong to the glymphatic system[5]
Radiology
- ultra-high-field 7T MRI used to identify enlarged perivascular spaces in the centrum semiovale of patients with migraine
More general terms
Additional terms
References
- ↑ Jump up to: 1.0 1.1 Romero JR et al. MRI visible perivascular spaces and risk of incident dementia: The Framingham Heart Study. Neurology 2022 Sep 29; [e-pub]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/36175148 https://n.neurology.org/content/early/2022/09/29/WNL.0000000000201293
- ↑ Jump up to: 2.0 2.1 Susman E Ultra-High-Res MRI Highlights Migraine Brain Changes. Patients had significant changes in perivascular spaces. MedPage Today December 1, 2022 https://www.medpagetoday.com/meetingcoverage/rsna/101993
- ↑ Jump up to: 3.0 3.1 Wardlaw JM, Benveniste H, Nedergaard M et al Perivascular spaces in the brain: anatomy, physiology and pathology Nat Rev Neurol. 2020 Mar;16(3):137-153. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32094487 Review.
- ↑ Jump up to: 4.0 4.1 Ineichen BV, Okar SV, Proulx ST et al Perivascular spaces and their role in neuroinflammation Neuron. 2022 Nov 2;110(21):3566-3581. PMID: https://www.ncbi.nlm.nih.gov/pubmed/36327898 Review.
- ↑ Jump up to: 5.0 5.1 5.2 Gouveia-Freitas K, Bastos-Leite AJ. Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology. Neuroradiology. 2021 Oct;63(10):1581-1597. PMID: https://www.ncbi.nlm.nih.gov/pubmed/34019111 PMCID: PMC8460534 Free PMC article. Review.
- ↑ Jump up to: 6.0 6.1 Lynch M, Pham W, Sinclair B et al Perivascular spaces as a potential biomarker of Alzheimer's disease Front Neurosci. 2022 Oct 18;16:1021131. PMID: https://www.ncbi.nlm.nih.gov/pubmed/36330347 PMCID: PMC9623161 Free PMC article. Review.