extended spectrum beta lactamase (ESBL)
Jump to navigation
Jump to search
Introduction
In reference to bacteria that produce beta-lactamase(s) resistant to extended spectrum antibiotics.
Epidemiology
- Enterobacteriaceae with carbapenemases decreased more from 2006-1015 than the extended spectrum beta lactamase phenotype[3]
Management
- carbapenems are appropriate for empiric therapy of infections due to extended spectrum beta-lactamase producing gram-negative bacteria
- ventilator-associated pneumonia[1]
- piperacillin tazobactam (Zosyn) inferior to meropenem[4]
- maintain contact precautions throughout hospitalization after 1st detected[2]
- ventilator-associated pneumonia[1]
More general terms
Additional terms
References
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 17, 18, 19. American College of Physicians, Philadelphia 2015, 2018, 2021.
- ↑ 2.0 2.1 Banach DB, Bearman G, Barnden M et al Duration of Contact Precautions for Acute-Care Settings. Infection Control & Hospital Epidemiology. Jan 11, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29321078 https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/duration-of-contact-precautions-for-acutecare-settings/94E38FDCE6E1823BD613ABE4E8CB5E56
- ↑ 3.0 3.1 Woodworth KR, Walters MS, Weiner LM, et al. Vital Signs: Containment of Novel Multidrug-Resistant Organisms and Resistance Mechanisms - United States, 2006-2017. MMWR Morb Mortal Wkly Rep. ePub: 3 April 2018. https://www.cdc.gov/mmwr/volumes/67/wr/mm6713e1.htm
- ↑ 4.0 4.1 Harris PNA, Tambyah PA, Lye DC et al Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance. A Randomized Clinical Trial. JAMA. 2018;320(10):984-994. Sept 11, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/30208454 https://jamanetwork.com/journals/jama/fullarticle/2702145
Hayden MK, Won SY. Carbapenem-Sparing Therapy for Extended-Spectrum beta-lactamase- producing E coli and Klebsiella pneumoniae Bloodstream Infection: The Search Continues. JAMA. 2018;320(10):979-981. Sept 11, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/30208439 https://jamanetwork.com/journals/jama/fullarticle/2702126