efgartigimod alfa-fcab (Vyvgart)
Jump to navigation
Jump to search
Indications
- treatment of generalized myasthenia gravis (gMG) in adult patients who are anti-acetylcholine receptor (AChR) antibody positive.
Dosage
- recommended dosage is 10 mg/kg administered as an intravenous infusion over one hour once weekly for 4 weeks
- in patients weighing >= 120 kg, the recommended dose is 1200 mg per infusion.
Injection: 400 mg in 20 mL (20 mg/mL) single-dose vial
Adverse effects
- hypersensitivity reactions: angioedema, dyspnea, & rash
- common (>= 10%): respiratory tract infections, headache, urinary tract infection
Mechanism of action
- human IgG1 antibody fragment that binds to & inhibits the neonatal Fc receptor resulting in the reduction of circulating IgG
More general terms
Component of
References
- ↑ Wikipedia: Efgartigimod alfa https://en.wikipedia.org/wiki/Efgartigimod_alfa
- ↑ HIGHLIGHTS OF PRESCRIBING INFORMATION VYVGART. (efgartigimod alfa-fcab) injection, for intravenous use