alpha-gal syndrome

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Etiology

Epidemiology

  • see lone star tick
  • suspected cases predominantly occurred in counties within the southern, midwestern, & mid-Atlantic U.S.[2]
  • patients with alpha-gal syndrome report a higher frequency of tick bites (RR=26)[5]

Pathology

Clinical manifestations

* carbohydrate alpha-gal is bound to lipid

* lipids are absorbed into the gut and circulation more slowly than proteins

Laboratory

Management

More general terms

Additional terms

References

  1. Rothaus C Hunting for a Diagnosis NEJM Resident 360. Feb 3, 2021 https://resident360.nejm.org/clinical-pearls/hunting-for-a-diagnosis
  2. Jump up to: 2.0 2.1 Thompson JM, Carpenter A, Kersh GJ, Wachs T, Commins SP, Salzer JS. Geographic Distribution of Suspected Alpha-gal Syndrome Cases - United States, January 2017-December 2022. MMWR Morb Mortal Wkly Rep 2023;72:815-820. Jyly 28. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37498787 https://www.cdc.gov/mmwr/volumes/72/wr/mm7230a2.htm
  3. Jump up to: 3.0 3.1 Carpenter A, Drexler NA, McCormick DW, et al. Health Care Provider Knowledge Regarding Alpha-gal Syndrome - United States, March-May 2022. MMWR Morb Mortal Wkly Rep 2023;72:809-814. July 28 PMID: https://www.ncbi.nlm.nih.gov/pubmed/37498792 https://www.cdc.gov/mmwr/volumes/72/wr/mm7230a1.htm
  4. Centers for Disease Control & Prevention (CDC) Alpha-gal Syndrome (AGS) 2022 Case Definition https://ndc.services.cdc.gov/case-definitions/alpha-gal-syndrome-ags/
  5. Jump up to: 5.0 5.1 5.2 5.3 5.4 Lesmana E, Rao S, Keehn A, Edwinson AL, Makol A, Grover M. Clinical Presentation and Outcomes of Alpha-Gal Syndrome. Clin Gastroenterol Hepatol. 2025 Jan;23(1):69-78. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39067555 https://www.cghjournal.org/article/S1542-3565(24)00672-4/fulltext

Patient information

alpha-gal syndrome patient information