histone H2B type 2-E1 (H2BE1)

Function

• core component of nucleosome
• nucleosomes wrap & compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template
• histones thud play a role in transcription regulation, DNA repair, DNA replication & chromosomal stability.
• DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, & nucleosome remodeling
• the nucleosome is a histone octamer containing two moleculeseach of H2A, H2B, H3 & H4 assembled in one H3-H4 heterotetramer & two H2A-H2B heterodimers
• the octamer wraps approximately 147 bp of DNA

Structure

belongs to the histone H2B family,

Compartment

• chromosome
• nucleus

More general terms

• histone-H2B

Database

• UniProt: http://www.uniprot.org/uniprot/A0A2R8Y619.html