Bargin; chimeric SH3BP1-PDXP protein (BARGIN)

Function

• GTPase activating protein (GAP)
• specifically converts GTP-bound RAC1 & CDC42 in their inactive GDP-bound form.
• GAP activity is enhanced by the non-covalent binding of K-29 & K-48 polyubiquitin chains

Compartment

• cell membrane, peripheral membrane protein
  • localization to membranes is increased by binding of polyubiquitin chains
• cytoplasm

Alternative initiation

Named isoforms=5

Expression

expressed in brain (at protein level)

Pathology

• enriched in tangle aggregates in cells of Alzheimer's disease brain

Notes

translation initiation occurs at a non-canonical CUG codon

More general terms

• GTPase-activating protein (GAP)

Database

• UniProt: http://www.uniprot.org/uniprot/Q6ZT62.html