EEF1AKMT4-ECE2 readthrough transcript protein; includes: methyltransferase-like region & endothelin-converting enzyme 2 region (EEF1AKMT4-ECE2)

Function

• converts big endothelin-1 to endothelin-1
• may also have methyltransferase activity (putative)
• may play a role in amyloid-beta processing (putative)

Cofactor: binds 1 Zn+2 per subunit

Structure

• in the N-terminal section; belongs to the methyltransferase superfamily
• in the C-terminal section; belongs to the peptidase M13 family

Compartment

• Golgi apparatus membrane., single-pass membrane protein
• cytoplasmic vesicle, secretory vesicle membrane

Alternative splicing

• named isoforms=5; EEF1AKMT4-ECE2-1; ECE2-1; ECE2-2; ECE2-3; EEF1AKMT4-1

More general terms

• endothelin-converting enzyme
• methyltransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=110599
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9718
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:110599
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9718
• OMIM: https://mirror.omim.org/entry/610145
• UniProt: http://www.uniprot.org/uniprot/P0DPD8.html