RNA vaccine

Indications

• treatment of cutaneous melanoma, including late-stage melanoma

Advantages

• can be produced rapidly
• elicit both antibody & T-cell responses

Procedure

• typically enclosed in lipid nanocapsules
• injected & taken up by host dendritic cells
  • the dendritic cells produce mRNA-encoded peptides (immunogens) in conjunction with major histocompatibility complex I proteins to elicit T-cell response

More general terms

• vaccine