ploidy measurement; somatic copy number alterations (SCNA)

^[1]

Clinical significance

may be prognostic markers for range of different cancers
neoplastic cells may be polyploid or aneuploid
tumor aneuploidy correlates with markers of immune evasion & with reduced response to immunotherapy^[1]

↑ ^1.0 ^1.1 Kerr DJ Overlooked Biomarker May Predict Cancer Immunotherapy Response. Medscaape. Feb 15, 2018 https://www.medscape.com/viewarticle/892475
Davoli T, Uno H, Wooten EC, Elledge SJ. Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy. Science. 2017 Jan 20;355(6322) pii: eaaf8399 PMID: https://www.ncbi.nlm.nih.gov/pubmed/28104840 Free PMC Article