pentagastrin (Peptavlon)

Indications

• pentagastrin-stimulated calcitonin test

Dosage

• injection 5 ug/kg ideal body weight

Adverse effects

• panic attack due to activation of cholecystokinin-B receptor

Mechanism of action

• synthetic polypeptide with gastrin-like effect
  • stimulates the secretion of gastric acid, pepsin, & intrinsic factor
  • binds to the cholecystokinin-B receptor, widely expressed in brain, in turn activating phospholipase C

More general terms

• polypeptide
• endocrine agent

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=9853654