edonerpic (T-817)
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Contraindications
- of no benefit in treating patients with mild-to-moderate Alzheimer's disease[1]
Mechanism of action
- unclear
- may target opioid sigma receptors in the brain
- may activate microglia to clear amyloid
- in animal models, attenuates toxic effect of beta-amyloid
Clinical trials
- NOBLE trial reported at AAIC 2017[1]
More general terms
References
- ↑ 1.0 1.1 1.2 Fiore K Novel Drug Doesn't Help Cognition in Alzheimer's - Questions about mechanism of action remain. MedPage Today. July 19, 2017 https://www.medpagetoday.com/MeetingCoverage/AAIC/66717