Pittsburgh compound B [C11] (PIB)
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Indications
- PET scan imaging of brain for Alzheimer's disease[1]
- PET scan imaging of brain for cerebral amyloid angiopathy[2]
Mechanism of action
- C11-labeled agent that binds fibrillar amyloid
- does not distinguish amyloid plaques of Alzheimer's disease from vascular amyloid of cerebral amyloid angiopathy
More general terms
References
- ↑ 1.0 1.1 Archer HA et al, Amyloid load and cerebral atrophy in Alzheimer's disease: An 11C-PIB positron emission tomography study. Ann Neurol 2006, 60:145 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16802294
- ↑ 2.0 2.1 Johnson K et al, Imaging of amyloid burden and distribution in cerebral amyloid angiopathy. Ann Neurol 2007, 62:229 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17683091
- ↑ Ly JV et al. 11C-PIB binding is increased in patients with cerebral amyloid angiopathy-related hemorrhage. Neurology 2010 Feb 9; 74:487. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20142615