maraviroc (Selzentry)
Jump to navigation
Jump to search
Indications
- adjunctive treatment of multi-drug resistant HIV
- susceptibility testing required prior to initiating treatment
Contraindications
Dosage
Pharmacokinetics
Adverse effects
- hypersensitivity
- hepatotoxicity masquerading as systemic allergic reaction
Drug interactions
- drugs that inhibit CYP3A4 inhibitors
- some antifungals, most protease inhibitors half the maraviroc dose
- drugs that induce CYP3A4
- some seizure meds, rifampin, efavirenz
- double the maraviroc dose
- avoid St John's wort, can lower maraviroc level
Laboratory
- CCR5 receptor testing[3]
- maraviroc in serum/plasma
Mechanism of action
- inhibits entry of HIV1 into cells when HIV1 uses CCR5 to gain entry into cells (50-60% of HIV1 strains)
More general terms
References
- ↑ Prescriber's Letter 14(9): 2007 New Drug: Selzentry (Maraviroc) Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=230904&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ Gulick RM et al Maraviroc for Previously Treated Patients with R5 HIV-1 Infection NEJM 359:1429-1441 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18832244
- ↑ 3.0 3.1 Aberg JA et al Primary care guidelines for the management of persons infected with human immunodeficiency virus: 2009 update by the HIV medicine Association of the Infectious Diseases Society of America. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19640227
- ↑ 4.0 4.1 Zuger A Use of Antiretroviral Drugs in Pregnancy. Physician's First Watch, April 22, 2014 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
Panel on Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission. Recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV transmission in the United States. 2014. AIDSinfo. Clinical Guidelines Portal. March 28, 2014. http://aidsinfo.nih.gov/Guidelines/HTML/3/perinatal-guidelines/0 (corresponding NGC guideline withdrawn March 2016) - ↑ Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015