sarcoplasmic/endoplasmic reticulum Ca+2 ATPase regulator DWORF; SERCA regulator DWORF; Dwarf open reading frame; DWORF ()

Function

• enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thus regulating skeletal muscle activity
• does not directly stimulate SERCA pump activity
• enhances sarcoplasmic reticulum Ca+2 uptake & myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN) & myoregulin (MRLN)
• interacts with ATP2A1/SERCA1

Compartment

• sarcoplasmic reticulum membrane
• single-pass membrane protein

More general terms

• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/P0DN84.html