sarcoplasmic/endoplasmic reticulum Ca+2 ATPase 1; Ca+2 ATPase (fast-twitch); Ca+2 pump 1; SR Ca+2-ATPase 1, endoplasmic reticulum class 1/2 Ca+2 ATPase (SERCA1, ATP2A1)

Introduction

Sarcoplasmic reticulum Ca+2-ATPase of fast twitch skeletal muscle.

Function

• catalyzes hydrolysis of ATP coupled with translocation of calcium from cytosol to sarcoplasmic reticulum lumen
• contributes to calcium sequestration in muscular excitation/ contraction
• interactions with phospholamban, sarcolipin Alternative slicing: SERCA1A, SERCA1B

Pathology

mutations associated with Brody myopathy

Genetics

gene locus: 16p12.1

More general terms

• sarcoplasmic/endoplasmic reticulum calcium ATPase

Additional terms

• Brody myopathy

Database

• OMIM: https://mirror.omim.org/entry/108730
• OMIM: https://mirror.omim.org/entry/601003
• UniProt: http://www.uniprot.org/uniprot/O14983.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=487