myoregulin (MLN)

Function

• inhibits activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing affinity of the ATPase for Ca+2, thus acting as a regulator of skeletal muscle activity
• high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle
• interacts with ATP2A1/SERCA1

Compartment

• sarcoplasmic reticulum membrane
• single-pass membrane protein

Expression

• high expression in adult skeletal muscle

More general terms

• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/P0DMT0.html