glomerular basement membrane (GBM) antibody in serum

Indications

• anti-glomerular basement membrane [GBM] disease
• Goodpasture's syndrome
• tubulointerstitial nephritis

Clinical significance

• associated with:
  • anti-glomerular basement membrane [GBM] disease
    • Goodpasture's syndrome (> 90% sensitivity & specificity)
  • tubulointerstitial nephritis
• the antigen is an epitope from type 4 collagen found in alveolar & glomerular basement membranes

Methods

indirect immunofluorescence

Specimen

• serum
• store at -20 degrees C

More general terms

• basement membrane antibody in serum

Additional terms

• anti-glomerular basement membrane (GBM) antibody
• anti-glomerular basement membrane [GBM] disease
• glomerular basement membrane (GBM)
• Goodpasture's syndrome