keratin-associated protein 4-16; keratin-associated protein 4 pseudogene 1; keratin-associated protein 4-16 pseudogene (KRTAP4-16, KRTAP4-16P, KRTAP4P1)

Function

• in the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), essential for formation of a rigid & resistant hair shaft via extensive disulfide bond cross-linking with abundant Cys of <A128357>hair keratins</A128357>
• the matrix proteins include the high-sulfur & high-Gly-Tyr keratins
• interacts with hair keratins

Structure

• belongs to the KRTAP type 4 family,

Polymorphism

• numerous size polymorphisms are present in KRTAP4 gene family, which are mainly due to variations in the sequence encoding cysteine-rich repeat segments

Notes

could be the product of a pseudogene

More general terms

• ketatin-associated protein (KRTAP)

Database

• UniProt: http://www.uniprot.org/uniprot/G5E9R7.html