transcriptional regulator PINT87aa (LINC-PINT)

Function

• enhances binding of the PAF1 complex to target gene promoters
• plays a role in negative regulation of transcription
• may function as an anchor to keep the PAF1 complex on target gene promoters, sequentially pausing RNA polymerase II-induced mRNA elongation
• inhibits FOXM1-mediated transcription of PHB2
• interacts with PAF1 complex member PAF1
• interacts with transcription factor FOXM1

Compartment

• nucleus

Expression

• expressed in brain, liver, kidney & stomach with lower levels in breast, intestine, thyroid & pancreas

Notes

• encoded by the circular form of the long non-coding RNA LINC-PINT
• suppresses glioblastoma cell proliferation & shows decreased expression in glioblastomas compared to normal non-tumor brain tissue
• induces growth inhibition & cellular sensescence & decreases mitophagy in hepatocellular carcinoma (HCC) cells with higher levels of expression in non-tumor tissue than in adjacent HCC tissue

More general terms

• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/A0A455ZAR2.html