forkhead box protein M1; forkhead-related protein 16; hepatocyte nuclear factor 3 forkhead homolog 11; M-phase phosphoprotein 2 (FOXM1, FKHL16, HFH11)
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Function
- transcriptional activation
- role in control of cell proliferation (putative)
- hosphorylated in M phase (mitosis)
Structure
- contains 1 fork-head DNA-binding domain
- within the protein there is a domain which acts as a transcriptional activator
Compartment
Alternative splicing
named isoforms=3
- isoforms 1 & 2 appear to be the only activatorsof gene transcription
- isoform 3, found in rat, does not seem to exist in human
Expression
- expressed in thymus, testis, small intestine,colon > ovary
- expressed only in adult organs containing proliferating cells or in response to growth factors
- expressed in epithelial cell lines derived from tumors
- not expressed in resting cells
- embryonic expression pattern: liver, lung, intestine, kidney, urinary tract
- adult expression pattern: intestine, colon, testis, thymus
- induced during liver regeneration & oxidative stress