C-C motif chemokine 17; CC chemokine TARC; small-inducible cytokine A17; thymus & activation-regulated chemokine (CCL17 SCYA17 TARC)

Function

• chemotactic factor for T-lymphocytes
• not chemotactic for monocytes or granulocytes
• may play a role in T-cell development in thymus & in trafficking & activation of mature T-cells
• binds to CCR4

Structure

• belongs to the intercrine beta (chemokine CC) family

Compartment

secreted

Expression

• expressed in thymus > lung, colon & small intestine
• induced by phytohemagglutinin (PHA) in peripheral blood mononuclear cells & by cytokines in monocytes

Laboratory

• chemokine (C-C motif) ligand 17 in serum

More general terms

• CC chemokine; beta chemokine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6361
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6361
• OMIM: https://mirror.omim.org/entry/601520
• UniProt: http://www.uniprot.org/uniprot/Q92583.html