estriol in 24 hour urine

Reference interval

• adult
• male: 1.0-11.0 ug/day (3.5-38 nmol/day)
• female
  • follicular phase: 0-15 ug/day (0-52 nmol/day)
  • ovulatory phase: 13-54 ug/day (45-187 nmol/day)
  • luteal phase: 8-60 ug/day (28-208 nmol/day)
  • postmenopausal: 0-11 ug/day (0-38 nmol/day)
  • pregnancy
    • 1st trimester: 0-800 ug/day (0-2776 nmol/day)
    • 2nd trimester: 0.8-1.2 mg/day (2.8-42 umol/day)
    • 3rd trimester: 5-50 mg/day (17-174 umol/day)

Clinical significance

• estriol is the predominant urinary estrogen during pregnancy
• serial measurement reflects the integrity of the fetus-placenta complex

Increases

• corticotropin (prenancy)
• spironolactone (males)

Decreases

• ampicillin
• neomycin
• oral contraceptives
• probenecid
• thyroxine

Specimen

• urine, 24 hours
• preserve with boric acid or thimerosal (25 mg/L)
• refrigerate during & after collection
• specify gestational age

More general terms

• estriol in urine
• 24 hour urine

Additional terms

• estriol (E3)