anorexia-cachexia syndrome

^[1]^[2]^[3]^[4]

Etiology

appetite stimulants do not improve morbidity or mortality (see anorexia)^[3]
artificial nutrition does not improve morbidity or mortality^[3]
olanzapine may improve appetite, weight & quality of life in patients with metastatic cancer^[4]

↑ Geriatric Review Syllabus, 9th edition (GRS9) Medinal-Walpole A, Pacala JT, Porter JF (eds) American Geriatrics Society, 2016
↑ Ruiz Garcia V et al Megestrol acetate for treatment of anorexia-cachexia syndrome. Cochrane Database Syst Rev. 2013 Mar 28;(3):CD004310. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23543530
↑ ^3.0 ^3.1 ^3.2 Medical Knowledge Self Assessment Program (MKSAP) 19 Board Basics. An Enhancement to MKSAP19. American College of Physicians, Philadelphia 2022
↑ ^4.0 ^4.1 Sandhya L et al. Randomized double-blind placebo-controlled study of olanzapine for chemotherapy- related anorexia in patients with locally advanced or metastatic gastric, hepatopancreaticobiliary, and lung cancer. J Clin Oncol 2023 May 10; 41:2617 PMID: https://www.ncbi.nlm.nih.gov/pubmed/36977285 Clinical Trial. https://ascopubs.org/doi/10.1200/JCO.22.01997
Roeland EJ, Bohlke K, Baracos VE et al Cancer Cachexia: ASCO Guideline Rapid Recommendation Update. J Clin Oncol. 2023 Sep 1;41(25):4178-4179. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37467399