IgA pemphigus

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^[1]^[2]

Pathology

subcorneal neutrophils
epidermal acantholysis
tissue-bound & circulating IgA autoantibodies that target desmosomal proteins
deposits of intercellular IgA at epidermal surfaces

* histopathology images^[2]

Clinical manifestations

vesiculopustular eruption
formation of clear blisters that rapidly become pustules
distribution:
- trunk & proximal extremities
- relative sparing of mucous membranes

Laboratory

direct immunofluorescence

Differential diagnosis

linear IgA bullous dermatosis (IgA pemphigoid)

More general terms

pemphigus

Additional terms

linear IgA bullous dermatosis (IgA pemphigoid)

References

↑ Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015
↑ ^2.0 ^2.1 Sandhu N, Elston DM (images) Medscape: IgA Pemphigus http://emedicine.medscape.com/article/1063776-overview

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