cistauosis
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Pathology
- formation of a pathologic form of tau (cis P-tau) damages cellular infrastructure & leads to neuronal apoptosis
- over time, cistauosis spreads to other neurons
More general terms
Additional terms
- microtubule-associated protein tau (neurofibrillary tangle protein, paired helical filament-tau, PHF-tau, MAPT, MTBT1)
- paired helical filament (PHF)
References
- ↑ Kondo A et al. Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy. Nature 2015 Jul 23; 523:431 PMID: https://www.ncbi.nlm.nih.gov/pubmed/26176913