estriol in serum unconjugated

Indications

• evaluation of fetal distress & placental function in patients with complications, including
  • preeclampsia
  • fetal growth retardation
  • gestational diabetes
  • diabetes during pregnancy
  • Rh immunization
  • choriocarcinoma
  • hydatidiform mole
• component of Triple screen & Quad Screen for predicting risk of fetal chromosomal abnormalities
  • Down's syndrome
  • trisomy 21
• prenatal diagnosis of disorders of fetal steroid metabolism
  • Smith-Lemli-Opitz syndrome
  • X-linked ichthyosis
  • contiguous gene syndrome (placental sulfatase deficiency)
  • aromatase deficiency
  • fetal adrenal insufficiency
  • various forms of congenital adrenal hyperplasia

Increases

• hydrops fetalis in the presence of a dying fetus

Decreases

• anencephalic fetus

More general terms

• estriol in serum/plasma

Additional terms

• estriol (E3)
• estriol unconjugated [Multiple of the median] (MOM) adjusted in serum

Component of

• triple screen (triple test, maternal AFP, msAFP, 3-test screen)
• QUAD screen (quadruple test, quadruple screen, 4-test screen)
• fetal congenital anomalies 5 analyte panel