Rickettsia africae
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Introduction
Etiologic agent of African Tick-Bite Fever.
Epidemiology
- tick vectors of the amblyomma genus
- found in 15 African countries, including South Africa
- 2nd only to malaria as cause of febrile illness in travelers returning from Africa
Pathology
- endothelial damage in the microcirculation leads to increased vascular permeability
Clinical manifestations
- fever, headache, malaise, conjunctivitis, pharyngitis
- maculopapular, vesicular or petechial rash
- regional lymphadenopathy with eschar at site of tick bite
- lesions characteristic of vasculitis
Laboratory
Complications
Management
- doxycycline for 7-10 days
More general terms
Additional terms
References
- ↑ Bohaty BR, Hebert AA African Tick-Bite Fever after a Game-Hunting Expedition. N Engl J Med 2015; 372:e14. March 5, 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25738687 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMicm1312910
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 18, American College of Physicians, Philadelphia 2018