proapoptotic nucleolar protein 1 (PANO1, PANO)

Function

• apoptosis-inducing protein
• modulates tumor suppressor function of CDKN2A/p14ARF
• enhances stability of CDKN2A/p14ARF by protecting it from degradation
• may act as a tumor suppressor

Compartment

• nucleus, nucleolus
• colocalizes with CDKN2A/p14ARF in the nucleolus

Expression

• widely expressed
• up-regulated after serum withdrawal

More general terms

• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=101927
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:101927
• UniProt: http://www.uniprot.org/uniprot/I0J062.html