renal disease in pregnancy
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Complications
increased risk for
- pre-eclampsia
- acute renal failure
- progression of chronic renal failure to end-stage renal disease
- preterm delivery
- gestational hypertension
- intrauterine growth retardation
- fetal loss, stillbirth[1]
- kidney stones in 3rd trimester & 1st 3 months postpartum[2]
- most stones are calcium phosphate (hydroxyapatite)
Management
- renal transplant patients should wait at least 2 years after transplantation with a stable allograft & stable immunosuppression before attempting conception[1]
- immunsuppressive agents mycophenolate & sirolimus are teratogenic & must be discontinued prior to attempting conception
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References
- ↑ Jump up to: 1.0 1.1 1.2 Medical Knowledge Self Assessment Program (MKSAP) 18, American College of Physicians, Philadelphia 2018
- ↑ Jump up to: 2.0 2.1 Thongprayoon C, Vaughan LE, Chewcharat A et al. Risk of symptomatic kidney stones during and after pregnancy. Am J Kidney Dis 2021 Sep; 78:409. PMID: https://www.ncbi.nlm.nih.gov/pubmed/33867205 PMCID: PMC8384636 (available on 2022-09-01) https://www.ajkd.org/article/S0272-6386(21)00402-9/fulltext