reference values for CSF constituents

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Reference interval

for lumbar CSF

analyte % value plasma/CSF ratio
protein - 15-24 mg/dL (total) -
- prealbumin 2-7% (17.3 mg/L) 14
- albumin 56-76% (155 mg/L) 260
- alpha-1 globulin 2-7% - -
- alpha-2 globulin 4-12% - -
- ceruloplasmin - (1.0 mg/L) 370
- alpha-2 macroglobulin - (2.0 mg/L) 1100
- beta globulin 8-18% - -
- transferrin - (14.4 mg/L) 140
- fibrinogen - (0.6 mg/L) 4900
- beta-lipoprotein - (0.6 mg/L) 6200
- gamma globulin 3-12% - -
- IgG - (12.3 mg/L) 800
- IgA - (1.3 mg/L) 1300
- IgM - (0.6 mg/L) 1200

* % of CSF protein

mean CSF protein in infants:[2]

  • 1st month of life: 75 mg/dL
  • 2nd month of life: 59 mg/dL
  • 3rd month of life: 39 mg/dL

Reference values: for lumbar CSF (cont)

electrolyte value
- Na+ 135-150 meq/L
- K+ 2.6-3.0 meq/L
- Cl- 115-130 meq/L
- HCO3- 20-25 meq/L
- Ca+2 2.0-2.8 meq/L (1.0-1.4 mmol/L)
- Mg+2 2.4-3.0 meq/L (1.2-1.5 mmol/L)
- lactate 10-22 mg/dL (1.1-2.4 mmol/L)

Reference values: for CSF (cont)

analyte value
osmolality 280-300 mOsm/L
pH 7.28-7.32 (lumbar)
pH 7.32-7.34 (cisternal)
pCO2 44-50 mm Hg (lumbar)
pCO2 40-46 mm Hg (cisternal
pO2 40-44 mm Hg

Reference values: for other CSF analytes

analyte value SI units
* NH3 10-35 ug/dL (6-20 umol/L)
* glutamine 5-20 mg/dL (0.3-1.4 mmol/L)
* creatinine 0.6-1.2 mg/dL (45-92 umol/L)
* glucose 50-80 mg/dL (2.8-4.4 mmol/L)
* Fe+2/Fe+3 1-2 ug/dL (0.2-0.4 umol/L)
* Zn+2 2-6 ug/dL (0.3-0.9 umol/L)
* phosphorous 1.2-2.0 mg/dL (0.4-0.7 mmol/L)
* urea 6-16 mg/dL (2.0-5.7 mmol/L)
* urate 0.5-3.0 mg/dL (30-180 umol/L)
* total lipid 1-2 mg/dL -
electrolyte value
- Na+ 135-150 meq/L
- K+ 2.6-3.0 meq/L
- Cl- 115-130 meq/L
- HCO3- 20-25 meq/L
- Ca+2 2.0-2.8 meq/L (1.0-1.4 mmol/L)
- Mg+2 2.4-3.0 meq/L (1.2-1.5 mmol/L)
- lactate 10-22 mg/dL (1.1-2.4 mmol/L)

Reference values: for CSF (cont)

analyte value
osmolality 280-300 mOsm/L
pH 7.28-7.32 (lumbar)
pH 7.32-7.34 (cisternal)
pCO2 44-50 mm Hg (lumbar)
pCO2 40-46 mm Hg (cisternal
pO2 40-44 mm Hg

Reference values: for other CSF analytes

analyte value SI units
* NH3 10-35 ug/dL (6-20 umol/L)
* glutamine 5-20 mg/dL (0.3-1.4 mmol/L)
* creatinine 0.6-1.2 mg/dL (45-92 umol/L)
* glucose 50-80 mg/dL (2.8-4.4 mmol/L)
* Fe+2/Fe+3 1-2 ug/dL (0.2-0.4 umol/L)
* Zn+2 2-6 ug/dL (0.3-0.9 umol/L)
* phosphorous 1.2-2.0 mg/dL (0.4-0.7 mmol/L)
* urea 6-16 mg/dL (2.0-5.7 mmol/L)
* urate 0.5-3.0 mg/dL (30-180 umol/L)
* total lipid 1-2 mg/dL -

References

  1. Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 462
  2. Jump up to: 2.0 2.1 Byington CL et al. Normative cerebrospinal fluid profiles in febrile infants. J Pediatr 2011 Jan; 158:130. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20801462