adipogenesis regulatory factor; adipogenesis factor rich in obesity; adipose most abundant gene transcript 2 protein; adipose-specific protein 2; apM-2 (ADIRF AFRO APM2 C10orf116)

Function

• role in fat cell development
• promotes adipogenic differentiation & stimulates transcription initiation of master adipogenesis factors like PPARG & CEBPA at early stages of preadipocyte differentiation

Compartment

nucleus

Expression

• expressed in adipose tissue (at protein level)
• highly expressed in omental & subcutaneous adipose tissues
• expressed in heart, cornea, liver, kidney & spleen
• up-regulated during pre-adipocyte differentiation
• up-regulated following DNA damage induced by UV irradiation

Pharmacology

• overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin

More general terms

• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10974
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10974
• UniProt: http://www.uniprot.org/uniprot/Q15847.html