Cap methyltransferase 1; Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; Cap1 2'O-ribose methyltransferase 1; MTr1; hMTr1; FtsJ methyltransferase domain-containing protein 2; interferon-stimulated gene 95 kD protein; ISG95 (CMTR1, FTSJD2, KIAA0082, MTR1)

Function

• S-adenosyl-L-methionine-dependent methyltransferase
• mediates mRNA cap1 2'-O-ribose methylation to 5'-cap structure of mRNAs
• methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA & small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1)
• preference for cap0 transcripts
• Cap1 modification is linked to higher levels of translation
• may be involved in the interferon response pathway
• interacts with POLR2A (via C-terminus)

S-adenosyl-L-methionine + m(7)G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppRm-RNA

Structure

• contains 1 G-patch domain
• contains 1 RrmJ-type SAM-dependent 2'-O-MTase domain
• contains 1 WW domain

Compartment

nucleus

Expression

• induced by interferons alpha & beta, & by vaccinia virus infection

More general terms

• methyltransferase
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23070
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23070
• UniProt: http://www.uniprot.org/uniprot/Q8N1G2.html