Cap methyltransferase 2; Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2; Cap2 2'O-ribose methyltransferase 2; HMTr2; MTr2; FtsJ methyltransferase domain-containing protein 1; protein adrift homolog (CMTR2 AFT FTSJD1)

Function

• S-adenosyl-L-methionine (SAM)-dependent methyltransferase
• mediates mRNA cap2 2'-O-ribose methylation to the 5'mRNA-cap structure
• methylates ribose of the second nucleotide of an m(7)GpppG-capped mRNA & small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2)
• recognizes a guanosine cap on RNA independently of its N(7) methylation status
• displays cap2 methylation on both cap0 & cap1
• displays a preference for cap1 RNAs

S-adenosyl-L-methionine + m(7)G(5')pppRmpN-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppRmpNm-RNA

Structure

• contains 1 adrift-type SAM-dependent 2'-O-MTase domain

Compartment

• nucleus, cytoplasm, membrane
• single-pass membrane protein (putative)

More general terms

• methyltransferase
• nuclear protein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55783
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55783
• UniProt: http://www.uniprot.org/uniprot/Q8IYT2.html