leucovorin (Wellcovorin)

^[1]^[2]^[3]^[4]

Introduction

Tradename: Wellcovorin. (calcium leucovorin).

high dose methotrexate (10-15 mg/m2) rescue:
- 15 mg (10 mg/m2) every 6 hours for 10 doses starting 24 hours after after beginning methotrexate infusion
- IV administration if risk of vomiting
used in combination with 5-fluorouracil for treatment of advanced colon cancer
- 200 mg/m2 IV over 3 minutes followed by 5-fluorouracil 370 mg/m2 IV
- 20 mg/m2 IV followed by 5-fluoruracil 425 mg/m2 IV
- administer separately to avoid precipitation
megaloblastic anemia
- due to folate deficiency: 1 mg QD
- due to congenital deficiency of dihydrofolate reductase: 3-6 mg IM QD
adjunctive therapy with antimicrobial agents (pyrimethamine)
- 2-15 mg/day for 3 days or until blood counts are normal
- 6 mg/day needed for platelet counts < 100,000/mm3

Tabs: 5 mg, 25 mg

Powder for injection: 50, 100, 350 mg vials.

Injection: 3 mg/mL (1 mL)

↑ Physicians Desk Reference. 52nd edition, Medical Economics, 1998
↑ Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998 Department of Veterans Affairs, VA National Formulary
↑ Kaiser Permanente Northern California Regional Drug Formulary, 1998
↑ ^4.0 ^4.1 Medical Knowledge Self Assessment Program (MKSAP) 16, American College of Physicians, Philadelphia 2012