vedolizumab (Entyvio)

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Indications

Contraindications

* Pregnancy:

Laboratory

Mechanism of action

* reduces hospital admissions for inflammatory bowel disease[3]

* reduces frequency of flares & need for glucocorticoids[3]

More general terms

References

  1. 1.0 1.1 Feagan BG et al. Vedolizumab as induction and maintenance therapy for ulcerative colitis. N Engl J Med 2013 Aug 22; 369:699 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23964933 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1215734
    Sandborn WJ et al. Vedolizumab as induction and maintenance therapy for Crohn's disease. N Engl J Med 2013 Aug 22; 369:711 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23964933 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1215739
  2. 2.0 2.1 FDA News Release. May 20, 2014 FDA approves Entyvio to treat ulcerative colitis and Crohn's disease. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm398065.htm
  3. 3.0 3.1 3.2 Walsh N Vedolizumab Tx Cuts Admissions in IBD - Rate of flares and need for corticosteroids also decreased. MedPage Today. Dec 9, 2016 http://www.medpagetoday.com/MeetingCoverage/AIBD/61970
  4. 4.0 4.1 Highlights of Prescribing Information Entyvio (vedolizumab) for injection intravenous use https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/125476Orig1s046lbl.pdf
  5. 5.0 5.1 NEJM Knowledge+ Complex Medical Care