lipophilic statin
Jump to navigation
Jump to search
Indications
- may confer a survival advantage across different histologic sybtypes of ovarian cancer
Adverse effects
- discontinuation of lipophilic statin* increases risk of Parkinson's disease[1]
* lipophilic statins cross the blood brain barrier
- drug adverse effects of HMG CoA reductase inhibitors
- drug adverse effects of anti-hyperlipidemic agents
More general terms
More specific terms
- atorvastatin (Lipitor)
- cerivastatin; rivastatin (Baycol, Lipobay)
- lovastatin (Mevacor, Altocor, monacolin-K, Altoprev)
- mevastatin
- pitavastatin; nisvastatin; itavastatin (Livalo)
- simvastatin (Zocor)
References
- ↑ 1.0 1.1 Physician's First Watch, July 25, 2013 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
Lee Y-C et al. Discontinuation of statin therapy associates with Parkinson disease: A population <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23884037 <Internet> http://neurology.org/content/early/2013/07/24/WNL.0b013e31829d873c - ↑ Ingram I Yet Another Reason to Take Statins?
Retrospective study showed 40% reduction in mortality for ovarian cancer patients. MedPage Today June 23, 2020 https://www.medpagetoday.com/meetingcoverage/aacr/87219
Visvanathan K, et al Lipophilic statins show promise for treatment of epithelial ovarian cancer. American Association for Cancer Research (AACR) 2020; Abstract 5782.