mevastatin

Introduction

Mevastatin requires lactone hydrolysis for activation.

Adverse effects

• gastrointestinal
  • hepatitis
    • increased serum transaminases
• musculoskeletal
  • myopathy
    • myalgias
    • increased serum creatine kinase
    • rhabdomyolysis
    • renal failure
• potentially teratogenic

• drug adverse effects of HMG CoA reductase inhibitors
• drug adverse effects of anti-hyperlipidemic agents

Mechanism of action

• inhibition of HMG CoA reductase
• maximal effect (80 mg/day)
  • total cholesterol: decrease of 20%
  • LDL cholesterol: decrease of 32%
  • HDL cholesterol: increase of 4%
  • triglycerides: no change

More general terms

• lipophilic statin

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=64715
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=446154
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2854