anetoderma; dermatitis atrophicans maculosa

Classification

• inflammatory (Jadassohn-Pellizzari)
• noninflammatory (Schweninger-Buzzi)

Etiology

• primary (idiopathic)
• secondary:
  • preceded by an inflammatory or other skin pathology in the same location
• may be associated with systemic disease
• a familial form has been described

Pathology

• benign condition
• focal loss of dermal elastic tissue
• inflammatory & noninflammatory lesions are histologically similar

Clinical manifestations

• localized areas of flaccid or herniated saclike skin
• both inflammatory & noninflammatory lesions may be found in the same individual

Laboratory

• thyroid autoantibodies
  • anti-thyroid peroxidase Ab
  • anti-thyroglobulin Ab
  • anti-thyrotropin receptor Ab
• antiphospholipid antibody
  • lupus anticoagulant
  • anticardiolipin Ab
  • anti beta-2-glycoprotein 1 Ab
• as indicated
  • complement C3 in serum, complement C4 in serum
  • serology
    • antinuclear antibody
    • anti-Ro antibody
    • anti-La antibody
    • antimitochonrial antibody
    • anti-smooth muscle antibody
    • serum ACE activity
    • complete blood count
    • erythrocyte sedimentation rate
    • Lyme disease serology (titer)
    • PPD
    • RPR

Management

• no effective treatment
• surgical excision may be an option if lesions are small & few

More general terms

• skin disease (dermatologic disorder, dermatopathy, dermatosis)