neutral protamine Hagedorn (NPH) insulin

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Introduction

Intermediate-acting insulin (see insulin parenteral). Longer-acting than regular insulin.

Dosage

Pharmacokinetics

  • onset 1-3 hours
  • peak 4-10 hours
  • duration 10-18 hours

Notes

More general terms

Component of

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015
  2. 2.0 2.1 Lipska KJ, Parker MM, Moffet HH, Huang ES, Karter AJ Association of initiation of basal insulin analogs vs neutral protamine Hagedorn insulin with hypoglycemia-related emergency department visits or hospital admissions and with glycemic control in patients with type 2 diabetes. JAMA 2018 Jul 3; 320:53. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29936529 https://jamanetwork.com/journals/jama/fullarticle/2685850
    Crowley MJ, Maciejewski ML. Revisiting NPH insulin for type 2 diabetes: Is a step back the path forward? JAMA 2018 Jul 3; 320:38. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29936528 https://jamanetwork.com/journals/jama/fullarticle/2685849