neutral protamine Hagedorn (NPH) insulin
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Introduction
Intermediate-acting insulin (see insulin parenteral). Longer-acting than regular insulin.
Dosage
- generally QHS dosing
- also used in combination with regular insulin
Pharmacokinetics
- onset 1-3 hours
- peak 4-10 hours
- duration 10-18 hours
Notes
- hypoglycemia & glycemic control no better with detemir or glargine than with neutral protamine Hagedorn insulin[2]
More general terms
Component of
References
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015
- ↑ Jump up to: 2.0 2.1 Lipska KJ, Parker MM, Moffet HH, Huang ES, Karter AJ Association of initiation of basal insulin analogs vs neutral protamine Hagedorn insulin with hypoglycemia-related emergency department visits or hospital admissions and with glycemic control in patients with type 2 diabetes. JAMA 2018 Jul 3; 320:53. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29936529 https://jamanetwork.com/journals/jama/fullarticle/2685850
Crowley MJ, Maciejewski ML. Revisiting NPH insulin for type 2 diabetes: Is a step back the path forward? JAMA 2018 Jul 3; 320:38. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29936528 https://jamanetwork.com/journals/jama/fullarticle/2685849