pentraxin-related protein PTX3; tumor necrosis factor-inducible gene 14 protein; TSG-14 (PTX3, TNFAIP5, TSG14)

Function

• regulation of innate resistance to pathogens
• inflammatory reactions
• clearance of self-components (putative)
• female fertility (putative)
• binds to C1q

Structure

• homomultimer, disulfide-linked
• contains 1 pentraxin domain

Compartment

secreted

Expression

induced by interleukin-1 beta & TNF-alpha

More general terms

• pentraxin-2 (neuronal pentraxin, NPTX)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5806
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5806
• OMIM: https://mirror.omim.org/entry/602492
• UniProt: http://www.uniprot.org/uniprot/P26022.html