vectored immunoprophylaxis (vectored immunization)
Jump to navigation
Jump to search
Procedure
- genes for broadly neutralizing antibodies may be inserted into an adenovirus vector
- the vector can infect both dividing & nondividing cells & imparts little pathogenicity
- once injected intramuscularly, the vector produces antibodies continuously without involvement of the host's immune system
More general terms
References
- ↑ Balazs AB et al. Antibody-based protection against HIV infection by vectored immunoprophylaxis. Nature 2011 Nov 30; 481:81. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22139420
- ↑ Balazs AB et al. Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission. Nat Med 2014 Mar; 20:296. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24509526
Corey L and McElrath MJ. One shot forward for HIV prevention. Nat Med 2014 Mar 4; 20:241 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24603794