argininosuccinate lyase in serum

Reference interval

• 0-4 U/L

Clinical significance

• more sensitive than serum ALT or serum AST in detecting liver disease

Increases

• hepatitis
• cirrhosis
• diseases with secondary liver involvement
  • pulmonary disease
  • diabetes
  • congestive heart failure
  • post-GI surgical
    • cholecystectomy
    • gastrectomy
  • liver metastases

Decreases

• argininosuccinate lyase deficiency
• some autoimmune chronic hepatitis with antibodies to argininosuccinate lyase

Notes

• genetic assay available

More general terms

• argininosuccinate lyase measurement

Additional terms

• argininosuccinate
• argininosuccinate lyase (argininosuccinase, ASAL, ASL)
• argininosuccinate lyase deficiency; argininosuccinic aciduria; argininosuccinic acidemia