dalfopristin/quinupristin (Synercid)

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Indications

FDA approved for treatment of life-threatening infections associated with:

Dosage

  • 7.6 mg/kg IV every 8 hours
  • 10-20 mg/kg/day divided every 12 hours

Pharmacokinetics

  • 75% excreted in feces
  • 20% excreted in urine
  • elimination 1/2life is 1.3-1.5 hours
  • no dosage adjustment needed for elderly[5]

Antimicrobial activity

Adverse effects

(fairly toxic)

Drug interactions

Mechanism of action

More general terms

Components

References

  1. Micromedex vol 101
  2. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  3. Kaiser Permanente, Drug update 6/2000 & summer 2000
  4. Prescriber's Letter 13(3): 2006 Cytochrome P450 drug interactions Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220233&pb=PRL (subscription needed) http://www.prescribersletter.com
  5. 5.0 5.1 5.2 Norman, D, In: UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001
  6. 6.0 6.1 Deprecated Reference

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