colchicine/probenecid (ColBENEMID)

Introduction

colchicine 0.5 mg, probenecid 0.5 g.

Indications

• treatment of chronic, recurrent gouty arthritis

Contraindications

Pregnancy category D

Dosage

• adults:
• 1 tab QD for 1 week, then
• 1 tab BID

Adverse effects

• not common (1-10%)
  • flushing, headache, dizziness, rash, alopecia, anorexia, nausea/vomiting, diarrhea, abdominal pain, urinary frequency, aplastic anemia, leukopenia, agranulocytosis, hepatotoxicity including hepatic necrosis, myopathy, peripheral neuritis, uric acid stones, nephrotic syndrome, hypersensitivity reactions

Drug interactions

• methotrexate

More general terms

• pharmacologic combination

Components

• colchicine (Colcrys, Lodoco)
• probenecid (Benemid, Probalan)