amylase/lipase/protease; amylase/endopeptidase/lipase; pancrelipase (Viokase, Pancrease, Cotazym-S, Ku-Zyme, Creon-10, Ultrase-MT, Ultresa, Viokace, Pancrecarb, Zypatt, Zenpep)
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Classification
- Tradenames of FDA-approved products:
- Tradenames of other products in use before 2009
- Viokase, Pancrease, Cotazym-S, Ku-Zyme, Creon-10, Ultrase-MT
Indications
- replacement therapy in symptomatic treatment of malabsorption secondary to pancreatic exocrine deficiency of organic origin
Contraindications
Dosage
Amylase/lipase/protease combinations - USP units -
| Combination | lipase | amylase | protease |
|---|---|---|---|
| Cotazyme-S | 5000 | 20,000 | 20,000 |
| Pancrease | 4000 | 20,000 | 25,000 |
| Pancrease-MT(4) | 4000 | 12,000 | 12,000 |
| Pancrease-MT(10) | 10,000 | 30,000 | 30,000 |
| Pancrease-MT(16) | 16,000 | 48,000 | 48,000 |
| Viokase | 8000 | 30,000 | 30,000 |
| Ultrase MT12 | 12,000 | 39,000 | 39,000 |
| Ultrase MT18 | 18,000 | 58,500 | 58,500 |
| Ultrase MT120 | 20,000 | 65,000 | 65,000 |
Storage
Pharmacokinetics
elimination: Not absorbed
Adverse effects
- free of adverse effects at recommended dosage
- excessive dose may cause
- not common (1-10%)
- uncommon (< 1%)
- irritation of the mouth, dyspnea, bronchospasm, rash
Mechanism of action
More general terms
Additional terms
Components
References
- ↑ The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- ↑ Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
- ↑ Kaiser Permanente Northern California Regional Drug Formulary, 1998
- ↑ 4.0 4.1 Prescriber's Letter 17(10): 2010 Approved Pancreatic Enzyme Products Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=261009&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ FDA News Release: March 1, 2012 FDA approves two new pancreatic enzyme products to aid food digestion http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm294143.htm
- ↑ 6.0 6.1 Prescriber's Letter 21(6): 2014 Oral Meds to Keep in Original Containers Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=300622&pb=PRL (subscription needed) http://www.prescribersletter.com