methylcytosine dioxygenase TET3 (TET3, KIAA0401)

Function

• catalyzes conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC) (putative)

5-methylcytosine + 2-oxoglutarate + O2 =

5-hydroxymethylcytosine + succinate + CO2

Cofactor: binds 1 Fe+2 ion per subunit (putative)

Structure

belongs to the TET family

Alternative splicing

named isoforms=3

Expression

• expressed in colon, muscle, adrenal gland & peripheral blood lymphocytes
• expressed in fetal brain
• not expressed in adult brain

More general terms

• dioxygenase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=200424
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:200424
• OMIM: https://mirror.omim.org/entry/613555
• UniProt: http://www.uniprot.org/uniprot/O43151.html